Carla and Jon presented our work on human lung organoids and genetic phenotyping of pulmonary fibrosis at the 2018 FASEB Lung epithelium meeting - as usual, all sorts of interesting work going on from groups around the world!
Exciting work we performed in collaboration with Genentech has enabled the first study using whole-genome-sequencing to explore mechanisms of genetic risk for IPF. This study found that ~10% of IPF patients have mutations in genes known to be related to telomere biology, and that there was an inverse association of these mutations with the common IPF-associated polymorphism in the MUC5B promoter. Full text of the article published in Lancet Respiratory Medicine is available here.
November 11-13, 2017, Vanderbilt hosted the PFF Summit sponsored by the Pulmonary Fibrosis Foundation. This unique meeting brought together >800 patients, families, caregivers, physicians and other healthcare providers, research scientists and industry partners with the goal of working towards better treatments for patients with pulmonary fibrosis.