Genetic subtypes of IPF

Exciting work we performed in collaboration with Genentech has enabled the first study using whole-genome-sequencing to explore mechanisms of genetic risk for IPF. This study found that ~10% of IPF patients have mutations in genes known to be related to telomere biology, and that there was an inverse association of these mutations with the common IPF-associated polymorphism in the MUC5B promoter. Full text of the article published in Lancet Respiratory Medicine is available here.